SINANO OpenIR  > 纳米生物医学与安全研究部  > 王强斌团队
Ag2S Quantum Dot: A Bright and Biocompatible Fluorescent Nanoprobe in the Second Near-Infrared Window
Yan Zhang(张燕); Guosong Hong; Yejun Zhang(张叶俊); Guangcun Chen(陈光村); Feng Li(李峰); Hongjie Dai; Qiangbin Wang(王强斌)
2012-03
Source PublicationACS Nano
Volume6Issue:5Pages:3695-3702
Abstract

Ag2S quantum dots (QDs) emitting in the second near-infrared region (NIR-II, 1.0–1.4 μm) are demonstrated as a promising fluorescent probe with both bright photoluminescence and high biocompatibility for the first time. Highly selective in vitro targeting and imaging of different cell lines are achieved using biocompatible NIR-II Ag2S QDs with different targeting ligands. The cytotoxicity study illustrates the Ag2S QDs with negligible effects in altering cell proliferation, triggering apoptosis and necrosis, generating reactive oxygen species, and causing DNA damage. Our results have opened up the possibilities of using these biocompatible Ag2S QDs for in vivo anatomical imaging and early stage tumor diagnosis with deep tissue penetration, high sensitivity, and elevated spatial and temporal resolution owing to their high emission efficiency in the unique NIR-II imaging window.

KeywordAg2s Quantum Dot Near-infrared Cytotoxicity Cellular Imaging Biocompatibility
Indexed BySCI
Language英语
WOS IDWOS:000304231700007
Citation statistics
Cited Times:384[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinano.ac.cn/handle/332007/1007
Collection纳米生物医学与安全研究部_王强斌团队
Corresponding AuthorHongjie Dai; Qiangbin Wang(王强斌)
Recommended Citation
GB/T 7714
Yan Zhang,Guosong Hong,Yejun Zhang,et al. Ag2S Quantum Dot: A Bright and Biocompatible Fluorescent Nanoprobe in the Second Near-Infrared Window[J]. ACS Nano,2012,6(5):3695-3702.
APA Yan Zhang.,Guosong Hong.,Yejun Zhang.,Guangcun Chen.,Feng Li.,...&Qiangbin Wang.(2012).Ag2S Quantum Dot: A Bright and Biocompatible Fluorescent Nanoprobe in the Second Near-Infrared Window.ACS Nano,6(5),3695-3702.
MLA Yan Zhang,et al."Ag2S Quantum Dot: A Bright and Biocompatible Fluorescent Nanoprobe in the Second Near-Infrared Window".ACS Nano 6.5(2012):3695-3702.
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