SINANO OpenIR  > 纳米生物医学与安全研究部  > 戴建武团队
Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells
Li, N(李宁); Wang, L(王龙); Zhang, Q(张倩); Gao, S(高嵩); Song, Q(宋琴); Huang, R(黄荣); Liu, LW(刘立伟); Dai, JW(戴建武); Tang, ML(唐明亮); Cheng, GS(程国胜)
2013-03
Source PublicationSCIENTIFIC REPORTS
Volume3Issue:0
AbstractNeural stem cell (NSC) based therapy provides a promising approach for neural regeneration. For the success of NSC clinical application, a scaffold is required to provide three-dimensional (3D) cell growth microenvironments and appropriate synergistic cell guidance cues. Here, we report the first utilization of graphene foam, a 3D porous structure, as a novel scaffold for NSCs in vitro. It was found that three-dimensional graphene foams (3D-GFs) can not only support NSC growth, but also keep cell at an active proliferation state with upregulation of Ki67 expression than that of two-dimensional graphene films. Meanwhile, phenotypic analysis indicated that 3D-GFs can enhance the NSC differentiation towards astrocytes and especially neurons. Furthermore, a good electrical coupling of 3D-GFs with differentiated NSCs for efficient electrical stimulation was observed. Our findings implicate 3D-GFs could offer a powerful platform for NSC research, neural tissue engineering and neural prostheses.
Indexed BySCI
Language英语
WOS IDWOS:000316984600002
Citation statistics
Cited Times:330[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinano.ac.cn/handle/332007/1372
Collection纳米生物医学与安全研究部_戴建武团队
纳米器件及相关材料研究部_刘立伟团队
纳米生物医学与安全研究部_程国胜团队
Corresponding AuthorDai, JW(戴建武)
Recommended Citation
GB/T 7714
Li, N,Wang, L,Zhang, Q,et al. Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells[J]. SCIENTIFIC REPORTS,2013,3(0).
APA Li, N.,Wang, L.,Zhang, Q.,Gao, S.,Song, Q.,...&Cheng, GS.(2013).Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells.SCIENTIFIC REPORTS,3(0).
MLA Li, N,et al."Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells".SCIENTIFIC REPORTS 3.0(2013).
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