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题名: Investigation of acetylated chitosan microspheres as potential chemoembolic agents
作者: Zhou, Xuan(周旋) ; Kong, Ming ; Cheng, Xiaojie ; Li, Jingjing ; Li, Jing ; Chen, Xiguang
通讯作者: Zhou, Xuan(周旋)
关键词: Chitosan ; Cytotoxicity ; Hemocompatibility ; Hemolysis ; Microspheres ; Thrombogenicity
刊名: Colloids and surfaces. B, Biointerfaces
发表日期: 2014
卷: 123, 期:0, 页:387-94
收录类别: SCI
英文摘要:
The aim was to investigate the potential of chitosan microspheres (CMs) with 
 
different acetylation using as a chemoembolic agent. Chitosan microspheres (CMs) 
 
were prepared via water-in-oil (W/O) emulsification cross-linking method, and 
 
acetylated chitosan microspheres (ACMs) were obtained by acetylation of CMs. Next, 
 
we characterized the morphology, size, composition and degrees of deacetylation 
 
using scanning electron microscopy (TEM), dynamic laser light scattering (DLS), and 
 
Fourier transform infrared spectrometer (FTIR). All microspheres had smooth surfaces 
 
and good mechanical flexibility, and all could pass through a 5F catheter. The 
 
swelling rate (SR) of CMs decreased significantly with the increase of pH (4.0-10.0) 
 
but ACMs did not change under the same conditions. Protein absorption assays 
 
suggested that albumin was more greatly adsorbed on CMs than on ACMs. Furthermore, 
 
CMs caused more blood clots than ACMs. ACMs caused hemolysis less than CMs (<5% of 
 
the time). Data indicated that ACMs had more hemocompatibility. Cytotoxicity tests 
 
indicated that ACMs initially had less cell attached proliferation but increased 
 
with incubation. In contrast, the relative growth rate of mouse embryo fibroblasts 
 
(MEFs) on CMs decreased gradually. The results suggested that ACMs could stimulate 
 
the growth of MEFs, and CMs were not cytotoxic to MEFs. Thus, ACMs were more 
 
biocompatible with greater potential to be used as chemoembolic material.  
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/1855
Appears in Collections:纳米生物医学与安全研究部_朱毅敏团队_期刊论文

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Recommended Citation:
Zhou, Xuan,Kong, Ming,Cheng, Xiaojie,et al. Investigation of acetylated chitosan microspheres as potential chemoembolic agents[J]. Colloids and surfaces. B, Biointerfaces,2014,123(0):387-94.
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