SINANO OpenIR  > 纳米生物医学与安全研究部  > 张智军团队
Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs
Zhang LM; Xia JG; Zhao QH; Liu LW (刘立伟); Zhang ZJ (张智军)
2010-02-22
Source PublicationSmall
Issue4
Cooperation Status其它
AbstractA simple synthetic route for the preparation of functional nanoscale graphene oxide (NGO), a novel nanocarrier for the loading and targeted delivery of anticancer drugs, is reported. The NGO is functionalized with sulfonic acid groups, which render it stable in physiological solution, followed by covalent binding of folic acid (FA) molecules to the NGO, thus allowing it to specifically target MCF-7 cells, human breast cancer cells with FA receptors. Furthermore, controlled loading of two anticancer drugs, doxorubicin (DOX) and camptothecin (CPT), onto the FA-conjugated NGO (FA-NGO) via pi-pi stacking and hydrophobic interactions is investigated. It is demonstrated that FA-NGO loaded with the two anticancer drugs shows specific targeting to MCF-7 cells, and remarkably high cytotoxicity compared to NGO loaded with either DOX or CPT only. Considering that the combined use of two or more drugs, a widely adopted clinical practice, often displays much better therapeutic efficacy than that of a single drug, the controlled loading and targeted delivery of mixed anticancer drugs using these graphene-based nanocarriers may find widespread application in biomedicine.
KeywordCancer Therapy Cytotoxicity Drug Delivery Graphene Oxide Nanomaterials
Indexed BySCI ; EI
Language英语
WOS IDWOS:000275260100009
Citation statistics
Cited Times:1066[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinano.ac.cn/handle/332007/289
Collection纳米生物医学与安全研究部_张智军团队
纳米器件及相关材料研究部_刘立伟团队
Corresponding AuthorZhang ZJ (张智军)
Recommended Citation
GB/T 7714
Zhang LM,Xia JG,Zhao QH,et al. Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs[J]. Small,2010(4).
APA Zhang LM,Xia JG,Zhao QH,Liu LW ,&Zhang ZJ .(2010).Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs.Small(4).
MLA Zhang LM,et al."Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs".Small .4(2010).
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