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题名: The HGF inhibitory peptide HGP-1 displays promising in vitro and in vivo efficacy for targeted cancer therapy
作者: Chen, LS(陈丽莎); Li, CL(李春林); Zhu, YM(朱毅敏)
通讯作者: Zhu, YM (朱毅敏)
关键词: HGF targeting peptide ; HGF/MET signaling pathway ; cancer targeted therapy
刊名: ONCOTARGET
发表日期: 2015
卷: 6, 期:30, 页:14
收录类别: SCI
部门归属: 纳米生物医学与安全研究部
英文摘要: HGF/MET pathway mediates cancer initiation and development. Thus, inhibition on HGF-initiated MET signaling pathway would provide a new approach to cancer targeted therapeutics. In our study, we identified a targeting peptide candidate binding to HGF which was named HGF binding peptide-1 (HGP-1) via bacterial surface display methods coupled with fluorescence-activated cell sorting (FACS). HGP-1 showed the moderate affinity when determined with surface plasmon resonance (SPR) technique and high specificity in binding to HGF while assessed by fluorescence-based ELISA assay. The results from MTT and in vitro migration assay indicated that HGF-dependent cell proliferation and migration could be inhibited by HGP-1. In vivo administration of HGP-1 led to an effective inhibitory effect on tumor growth in A549 tumor xenograft models. Moreover, findings from Western Blots revealed that HGP-1 could down-regulated the phosphorylation levels of MET and ERK1/2 initiated by HGF, which suggested that HGP-1 could disrupt the activation of HGF/MET signaling to influence the cell activity. All the data highlighted the potential of HGP-1 to be a potent inhibitor for HGF/MET signaling.
语种: 英语
JCR小类分区: 一区
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/3294
Appears in Collections:纳米生物医学与安全研究部_朱毅敏团队_期刊论文

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Recommended Citation:
Chen, LS,Li, CL,Zhu, YM. The HGF inhibitory peptide HGP-1 displays promising in vitro and in vivo efficacy for targeted cancer therapy[J]. ONCOTARGET,2015,6(30):14.
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