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题名: Label-free Detection of Zn2+ Based on G-quadruplex
作者: Guo, YH(郭亚辉); Sun, Y(孙艳); Shen, XQ(申小强); Zhang, KC(张坤驰); Hu, JM; Pei, RJ(裴仁军)
通讯作者: Hu, JM
关键词: G-quadruplex ; thioflavin T ; Zn2+ detection ; label-free
刊名: ANALYTICAL SCIENCES
发表日期: 2015
卷: 31, 期:10, 页:5
收录类别: SCI
部门归属: 纳米生物医学与安全研究部
英文摘要: Herein, we developed a sensing strategy for the label-free detection of Zn2+ based on G-quadruplex. In the absence of Zn2+, there was a fluorescence enhancement of thioflavin T by interaction with human telomere sequence. On the addition of Zn2+, Zn2+ induced a more compact G-quadruplex structure to release thioflavin T, resulting in a fluorescence decrease. This simple "mix-then-detect" method gave the detection limit of 0.91 mu M with linear dynamic ranges from 0 to 10 mu M. Because it does not require the use of expensive and unstable DNAzyme systems, or need synthesis and modification of nanomaterials, this label-free biosensor is simple, fast, cost-effective and applicable for real samples taken from lake water.
语种: 英语
JCR小类分区: 四区
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/3297
Appears in Collections:纳米生物医学与安全研究部_裴仁军团队_期刊论文

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Recommended Citation:
Guo, YH,Sun, Y,Shen, XQ,et al. Label-free Detection of Zn2+ Based on G-quadruplex[J]. ANALYTICAL SCIENCES,2015,31(10):5.
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