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题名: Preoperative Detection and Intraoperative Visualization of Brain Tumors for More Precise Surgery: A New Dual-Modality MRI and NIR Nanoprobe
作者: Li, CY(李春炎); Cao, LM(曹利敏); Zhang, YJ(张叶俊); Yi, PW(易佩伟); Wang, M(王懋); Tan, B(谭波); Deng, ZW(邓宗武); Wu, DM(吴东岷); Wang, QB(王强斌)
通讯作者: Wang, QB (王强斌)
关键词: Ag2S QDs ; dual modality nanoprobes ; nanoprobes ; image-guided surgery ; magnetic resonance imaging ; near-infrared fluorescence
刊名: SMALL
发表日期: 2015
DOI: 10.1002/smll.201500997
卷: 11, 期:35, 页:9
收录类别: SCI
部门归属: 纳米生物医学与安全研究部
英文摘要: In clinical practice, it is difficult to identify tumor margins during brain surgery due to its inherent infiltrative character. Herein, a unique dual-modality nanoprobe (Gd-DOTA-Ag2S QDs, referred as Gd-Ag2S nanoprobe) is reported, which integrates advantages of the deep tissue penetration of enhanced magnetic resonance (MR) imaging of Gd and the high signal-to-noise ratio and high spatiotemporal resolution of fluorescence imaging in the second near-infrared window (NIR-II) of Ag2S quantum dots (QDs). Due to the abundant tumor angiogenesis and the enhanced permeability and retention effect in the tumor, a brain tumor (U87MG) in a mouse model is clearly delineated in situ with the help of the Gd assisted T1 MR imaging and the intraoperative resection of the tumor is precisely accomplished under the guidance of NIR-II fluorescence imaging of Ag2S QDs after intravenous injection of Gd-Ag2S nanoprobe. Additionally, no histologic changes are observed in the main organs of the mouse after administration of Gd-Ag2S nanoprobe for 1 month, indicating the high biocompatibility of the nanoprobe. We expect that such a novel Detection and Operation strategy based on Gd-Ag2S nanoprobe is promising in future clinical applications.
语种: 英语
JCR小类分区: 一区
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/3309
Appears in Collections:纳米研究国际实验室_吴东岷团队_期刊论文
纳米仿生研究部_邓宗武团队_期刊论文
纳米生物医学与安全研究部_王强斌团队_期刊论文

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Recommended Citation:
Li, CY,Cao, LM,Zhang, YJ,et al. Preoperative Detection and Intraoperative Visualization of Brain Tumors for More Precise Surgery: A New Dual-Modality MRI and NIR Nanoprobe[J]. SMALL,2015,11(35):9.
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