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题名: Aptamer-Modified Temperature-Sensitive Liposomal Contrast Agent for Magnetic Resonance Imaging
作者: Zhang, KC(张坤驰); Liu, M(刘敏); Tong, XY(仝晓艳); Sun, N(孙娜); Zhou, L(周璐); Cao, Y(曹翼); Wang, JE(王金娥); Zhang, HL(张海禄); Pei, RJ(裴仁军)
通讯作者: Zhang, HL (张海禄)
刊名: BIOMACROMOLECULES
发表日期: 2015
DOI: 10.1021/acs.biomac.5b00250
卷: 16, 期:9, 页:6
收录类别: SCI
部门归属: 纳米生物医学与安全研究部
英文摘要: A novel aptamer modified thermosensitive liposome was designed as an efficient magnetic resonance imaging probe. In this paper, Gd-DTPA was encapsulated into an optimized thermosensitive liposome (TSL) formulation, followed by conjugation with AS1411 for specific targeting against tumor cells that overexpress nucleolin receptors. The resulting liposomes were extensively characterized in vitro as a contrast agent. As-prepared TSLs-AS1411 had a diameter about 136.1 nrn. No obvious cytotoxicity was observed from MTT assay, which illustrated that the liposomes exhibited excellent biocompatibility. Compared to the control incubation at 37 degrees C, the liposomes modified with AS1411 exhibited much higher T-1 relaxivity in MCF-7 cells incubated at 42 degrees C. These data indicate that the Gd-encapsulated TSLs-AS1411 may be a promising tool in early cancer diagnosis.
语种: 英语
JCR小类分区: 二区
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/3319
Appears in Collections:纳米生物医学与安全研究部_裴仁军团队_期刊论文

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Recommended Citation:
Zhang, KC,Liu, M,Tong, XY,et al. Aptamer-Modified Temperature-Sensitive Liposomal Contrast Agent for Magnetic Resonance Imaging[J]. BIOMACROMOLECULES,2015,16(9):6.
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