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题名: Electrospun Collagen Fibers with Spatial Patterning of SDF1 alpha for the Guidance of Neural Stem Cells
作者: Li, XR(李晓然); Liang, H(梁辉); Sun, J(孙杰); Zhuang, Y(庄燕); Xu, B(徐白); Dai, JW(戴建武)
通讯作者: Dai, JW (戴建武)
刊名: ADVANCED HEALTHCARE MATERIALS
发表日期: 2015
DOI: 10.1002/adhm.201500271
卷: 4, 期:12, 页:8
收录类别: SCI
部门归属: 纳米生物医学与安全研究部
英文摘要: Producing gradients of biological cues into nerve conduits is crucial for nerve guidance and regeneration. Herein, the fabrication of gradients of stromal cell-derived factor-1 alpha (SDF1 alpha) on electrospun collagen mats is reported using an electrohydrodynamic jet printing technique. The fabrication of various SDF1 alpha gradated patterns on collagen fibrous mats is successfully demonstrated including shallow continuous gradient, steep continuous gradient, and step gradient by controlling the processing parameters. The SDF1 alpha graded collagen scaffolds show a long-term stable gradient, as SDF1 alpha is fused with a unique peptide of collagen binding domain (CBD), and CBD-SDF1 alpha can specifically bind to the collagen mat. Such graded scaffolds exhibit sustained release of SDF1 alpha. Further examination of neural stem cell (NSC) response to the CBD-SDF1 alpha gradients with various patterns show that the NSCs can sense the CBD-SDF1 alpha gradients, display a polarized morphology, and tend to migrate toward the region with a higher CBD-SDF1 alpha content. The collagen mats with CBD-SDF1 alpha gradients guide gradual distribution of NSCs, and NSC-differentiated neurons and astrocytes after seeding for 1 and 7 d. This new class of CBD-SDF1 alpha gradient scaffolds can potentially be employed for guided nerve regeneration.
语种: 英语
JCR小类分区: 一区
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/3325
Appears in Collections:纳米生物医学与安全研究部_戴建武团队_期刊论文

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Recommended Citation:
Li, XR,Liang, H,Sun, J,et al. Electrospun Collagen Fibers with Spatial Patterning of SDF1 alpha for the Guidance of Neural Stem Cells[J]. ADVANCED HEALTHCARE MATERIALS,2015,4(12):8.
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