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题名: Chimeric peptide constructs comprising linear B-cell epitopes: application to the serodiagnosis of infectious diseases
作者: Lu, YD(卢煜东); Li, Z; Teng, H; Xu, HK(徐宏科); Qi, SN; He, JA; Gu, DY; Chen, QJ; Ma, HW(马宏伟)
通讯作者: Chen, QJ
刊名: SCIENTIFIC REPORTS
发表日期: 2015
DOI: 10.1038/srep13364
卷: 5, 页:11
收录类别: SCI
部门归属: 纳米生物医学与安全研究部
英文摘要: Linear B-cell epitopes are ideal biomarkers for the serodiagnosis of infectious diseases. However, the long-predicted diagnostic value of epitopes has not been realized. Here, we demonstrated a method, diagnostic epitopes in four steps (DEIFS), that delivers a combination of epitopes for the serodiagnosis of infectious diseases with a high success rate. Using DEIFS for malaria, we identified 6 epitopes from 8 peptides and combined them into 3 chimeric peptide constructs. Along with 4 other peptides, we developed a rapid diagnostic test (RDT), which is able to differentiate Plasmodium falciparum (P. falciparum) from Plasmodium vivax (P. vivax) infections with 95.6% overall sensitivity and 99.1% overall specificity. In addition to applications in diagnosis, DEIFS could also be used in the diagnosis of virus and bacterium infections, discovery of vaccine candidates, evaluation of vaccine potency, and study of disease progression.
语种: 英语
JCR小类分区: 二区
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/3327
Appears in Collections:纳米生物医学与安全研究部_马宏伟团队_期刊论文

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Recommended Citation:
Lu, YD,Li, Z,Teng, H,et al. Chimeric peptide constructs comprising linear B-cell epitopes: application to the serodiagnosis of infectious diseases[J]. SCIENTIFIC REPORTS,2015,5:11.
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