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题名: One-step synthesis of fluorescent smart thermo-responsive copper clusters: A potential nanothermometer in living cells
作者: Wang, C; Ling, L; Yao, YG(姚亚刚); Song, QJ
通讯作者: Yao, YG (姚亚刚)
关键词: fluorescence ; copper nanoclusters ; cellular imaging ; nanothermometer
刊名: NANO RESEARCH
发表日期: 2015
DOI: 10.1007/s12274-015-0707-0
卷: 8, 期:6, 页:12
收录类别: SCI
部门归属: 先进材料研究部
英文摘要: Temperature measurement in biology and medical diagnostics, along with sensitive temperature probing in living cells, is of great importance; however, it still faces significant challenges. Metal nanoclusters (NCs) with attractive luminescent properties may be promising candidates to overcome such challenges. Here, a novel one-step synthetic method is presented to prepare highly fluorescent copper NCs (CuNCs) in ambient conditions by using glutathione (GSH) as both the reducing agent and the protective layer preventing the aggregation of the as-formed NCs. The resultant CuNCs, with an average diameter of 2.3 nm, contain 1-3 atoms and exhibit red fluorescence (lambda(em) = 610 nm) with high quantum yields (QYs, up to 5.0%). Interestingly, the fluorescence signal of the CuNCs is reversibly responsive to the environmental temperature in the range of 15-80 degrees C. Furthermore, as the CuNCs exhibit good biocompatibility, they can pervade the MC3T3-E1 cells and enable measurements over the physiological temperature range of 15-45 degrees C with the use of the confocal fluorescence imaging method. In view of the facile synthesis method and attractive fluorescence properties, the as-prepared CuNCs may be used as photoluminescence thermometers and biosensors.
语种: 英语
JCR小类分区: 一区
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内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/3362
Appears in Collections:先进材料研究部_姚亚刚团队_期刊论文

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Recommended Citation:
Wang, C,Ling, L,Yao, YG,et al. One-step synthesis of fluorescent smart thermo-responsive copper clusters: A potential nanothermometer in living cells[J]. NANO RESEARCH,2015,8(6):12.
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