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题名: In vivo real-time visualization of mesenchymal stem cells tropism for cutaneous regeneration using NIR-II fluorescence imaging
作者: Chen, GC(陈光村); Tian, F(田飞); Li, CY(李春炎); Zhang, YJ(张叶俊); Weng, Z; Zhang, Y; Peng, R; Wang, QB(王强斌)
通讯作者: Wang, QB (王强斌)
关键词: Mesenchymal stem cells ; Ag2S quantum dots ; In vivo near-infrared fluorescence imaging ; Cutaneous regeneration ; Stromal cell derived factor-1 alpha
刊名: BIOMATERIALS
发表日期: 2015
DOI: 10.1016/j.biomaterials.2015.02.090
卷: 53, 页:9
收录类别: SCI
部门归属: 纳米研究国际实验室
英文摘要: Mesenchymal stem cells (MSCs) have shown great potential for cutaneous wound regeneration in clinical practice. However, the in vivo homing behavior of intravenously transplanted MSCs to the wounds is still poorly understood. In this work, fluorescence imaging with Ag2S quantum dots (QDs) in the second near-infrared (NIR-II) window was performed to visualize the dynamic homing behavior of transplanted human mesenchymal stem cells (hMSCs) to a cutaneous wound in mice. Benefiting from the desirable spatial and temporal resolution of Ag2S QDs-based NIR-II imaging, for the first time, the migration of hMSCs to the wound was dynamically visualized in vivo. By transplanting a blank collagen scaffold in the wound to help the healing, it was found that hMSCs were slowly recruited at the wound after intravenous injection and were predominantly accumulated around the edge of wound. This resulted in poor healing effects in terms of slow wound closure and thin thickness of the regenerated skin. In contrast, for the wound treated by the collagen scaffold loaded with stromal cell derived factor-1 alpha (SDF-1 alpha), more hMSCs were recruited at the wound within a much shorter time and were homogenously distributed across the whole wound area, which enhances the re-epithelialization, the neovascularization, and accelerates the wound healing. (C) 2015 Elsevier Ltd. All rights reserved.
语种: 英语
JCR小类分区: 一区
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内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/3371
Appears in Collections:纳米生物医学与安全研究部_王强斌团队_期刊论文

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Recommended Citation:
Chen, GC,Tian, F,Li, CY,et al. In vivo real-time visualization of mesenchymal stem cells tropism for cutaneous regeneration using NIR-II fluorescence imaging[J]. BIOMATERIALS,2015,53:9.
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