中国科学院苏州纳米技术与纳米仿生研究所机构知识库
Advanced  
SINANO OpenIR  > 纳米生物医学与安全研究部  > 王强斌团队  > 期刊论文
题名: Controlled Self-Assembly of Proteins into Discrete Nanoarchitectures Templated by Gold Nanoparticles via Monovalent Interfacial Engineering
作者: Ma, LZ(马灵芝); Li, F; Fang, T; Zhang, JT(张建庭); Wang, QB(王强斌)
通讯作者: Li, F
关键词: self-assembly ; protein nanostructure ; discrete nanoarchitecture ; gold nanoparticle ; monofunctionalization
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2015
DOI: 10.1021/acsami.5b02823
卷: 7, 期:20, 页:8
收录类别: SCI
部门归属: 纳米研究国际实验室
英文摘要: Deigned rational assembly Of proteins promises novel properties and functionalities as well as new insights into the nature of life. De novo design of artificial protein nanostructures has been achieved Using protein subunits or peptides as building, blocks. However, controlled assembly of protein nanostructures into higher-order discrete nano architectures, rather than infinite arrays or aggregates, remains a challenge due to the complex or symmetric surface chemistry of protein nanostructures. Here we develop a facile strategy to control the hierarchical assembly of protein nanocages into discrete nanoarchitectures with gold nanoparticles (AuNPs), as scaffolds Via rationally designing their interfacial interaction. The protein nanocage is monofunctionalized with a polyhistidine tag (Histag) on the external surface through a mixed assembly strategy, while AuNPs, are modified with Ni2+-NTA chelates so that the protein nanocage can controllably assemble onto the AuNPs via the Histag-Ni2+ affinity. Discrete protein nanoarchitectures with: tunable composition can be generated by stoichiometric control over the ratio of protein nanocage to AuNP or change of AuNP size. The methodology described here is extendable to, other protein nanostructures and,chemically synthesized, nanomaterials, and can be borrowed by synthetic biology for biomicromolecule manipulation.
语种: 英语
JCR小类分区: 一区
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/3374
Appears in Collections:纳米生物医学与安全研究部_王强斌团队_期刊论文

Files in This Item:

There are no files associated with this item.


Recommended Citation:
Ma, LZ,Li, F,Fang, T,et al. Controlled Self-Assembly of Proteins into Discrete Nanoarchitectures Templated by Gold Nanoparticles via Monovalent Interfacial Engineering[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(20):8.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ma, LZ(马灵芝)]'s Articles
[Li, F]'s Articles
[Fang, T]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ma, LZ(马灵芝)]‘s Articles
[Li, F]‘s Articles
[Fang, T]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!