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题名: Real-time in vivo visualization of tumor therapy by a near-infrared-II Ag2S quantum dot-based theranostic nanoplatform
作者: Hu, F(胡峰); Li, CY(李春炎); Zhang, YJ(张叶俊); Wang, M(王懋); Wu, DM(吴东岷); Wang, QB(王强斌)
通讯作者: Wang, QB (王强斌)
关键词: in vivo imaging ; Ag2S quantum dots ; second near-infrared window fluorescence ; drug delivery ; tumor therapy
刊名: NANO RESEARCH
发表日期: 2015
DOI: 10.1007/s12274-014-0653-2
卷: 8, 期:5, 页:11
收录类别: SCI
部门归属: 纳米研究国际实验室
英文摘要: Real-time and objective feedback of therapeutic efficacies would be of great value for tumor treatment. Here, we report a smart Ag2S QD-based theranostic nanoplatform (DOX@PEG-Ag2S) obtained by loading the anti-cancer drug doxorubicin (DOX) into polyethylene glycol-coated silver sulfide quantum dots (PEG-Ag2S QDs) through hydrophobic-hydrophobic interactions, which exhibited high drug loading capability (93 wt.% of DOX to Ag2S QDs), long circulation in blood (t (1/2) = 10.3 h), and high passive tumor-targeting efficiency (8.9% ID/gram) in living mice where % ID/gram reflects the probe concentration in terms of the percentage of the injected dose (ID) per gram of tissue. After targeting the tumor tissue, DOX from PEG-Ag2S cargoes was selectively and rapidly released into cancer cells, giving rise to a significant tumor inhibition. Owing to the deep tissue penetration and high spatio-temporal resolution of Ag2S QDs fluorescence in the second near-infrared window (NIR-II), the DOX@PEG-Ag2S enabled real-time in vivo reading of the drug targeting process and therapeutic efficacy. We expect that such a novel theranostic nanoplatform, DOX@PEG-Ag2S, with integrated drug delivery, therapy and assessment functionalities, will be highly useful for personalized treatments of tumors.
语种: 英语
JCR小类分区: 一区
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内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/3383
Appears in Collections:纳米生物医学与安全研究部_王强斌团队_期刊论文

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Recommended Citation:
Hu, F,Li, CY,Zhang, YJ,et al. Real-time in vivo visualization of tumor therapy by a near-infrared-II Ag2S quantum dot-based theranostic nanoplatform[J]. NANO RESEARCH,2015,8(5):11.
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