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题名: Enhanced Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells on Graphene Oxide-Incorporated Electrospun Poly(lactic-co-glycolic acid) Nanofibrous Mats
作者: Luo, Y; Shen, H(沈贺); Fang, YX; Cao, YH(曹玉华); Huang, J; Zhang, MX(张萌欣); Dai, JW(戴建武); Shi, XY; Zhang, ZJ(张智军)
通讯作者: Dai, JW (戴建武)
关键词: nanofibrous mat ; electrospinning ; graphene oxide ; mesenchymal stem cells ; osteogenic differentiation ; tissue engineering
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2015
DOI: 10.1021/acsami.5b00862
卷: 7, 期:11, 页:9
收录类别: SCI
部门归属: 纳米生物医学与安全研究部
英文摘要: Currently, combining biomaterial scaffolds with living stem cells for tissue regeneration is a main approach for tissue engineering. Mesenchymal stem cells (MSCs) are promising candidates for musculoskeletal tissue repair through differentiating into specific tissues, such as bone, muscle, and cartilage. Thus, successfully directing the fate of MSCs through factors and inducers would improve regeneration efficiency. Here, we report the fabrication of graphene oxide (GO)-doped poly(lactic-co-glycolic acid) (PLGA) nanofiber scaffolds via electrospinning technique for the enhancement of osteogenic differentiation of MSCs. GO-PLGA nanofibrous mats with three-dimensional porous structure and smooth surface can be readily produced via an electrospinning technique. GO plays two roles in the nanofibrous mats: first, it enhances the hydrophilic performance, and protein- and inducer-adsorption ability of the nanofibers. Second, the incorporated GO accelerates the human MSCs (hMSCs) adhesion and proliferation versus pure PLGA nanofiber and induces the osteogenic differentiation. The incorporating GO scaffold materials may find applications in tissue engineering and other fields.
语种: 英语
JCR小类分区: 一区
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/3410
Appears in Collections:纳米生物医学与安全研究部_张智军团队_期刊论文

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Recommended Citation:
Luo, Y,Shen, H,Fang, YX,et al. Enhanced Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells on Graphene Oxide-Incorporated Electrospun Poly(lactic-co-glycolic acid) Nanofibrous Mats[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(11):9.
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