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题名: Manganese Doped Iron Oxide Theranostic Nanoparticles for Combined T-1 Magnetic Resonance Imaging and Photothermal Therapy
作者: Zhang, MX(张萌欣); Cao, YH(曹玉华); Wang, LN(王丽娜); Ma, YF(马宇飞); Tu, XL(涂小龙); Zhang, ZJ(张智军)
通讯作者: Zhang, ZJ (张智军)
关键词: magnetic nanoparticles ; MR imaging ; photothermal therapy ; theranostics
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2015
DOI: 10.1021/am5080453
卷: 7, 期:8, 页:9
收录类别: SCI
部门归属: 纳米生物医学与安全研究部
英文摘要: Photothermal therapy (PTT) is a noninvasive and convenient way to ablate tumor tissues. Integrating PTT with imaging technique could precisely identify the location and the size of tumor regions, thereby significantly improving the therapeutic efficacy. Magnetic resonance imaging (MRI) is widely used in clinical diagnosis due to its superb spatial resolution and real-time monitoring feature. In our work, we developed a theranostic nanoplatform based on manganese doped iron oxide (MnIO) nanoparticles modified with denatured bovine serum albumin (MnIO-dBSA). The in vitro experiment revealed that the MnIO nanoparticles exhibited T-1-weighted MRI capability (r(1) = 8.24 mM(-1) s(-1), r(2)/r(1) = 2.18) and good photothermal effect under near-infrared laser irradiation (808 nm). Using 4T(1) tumor-bearing mice as an animal model, we further demonstrated that the MnIO-dBSA composites could significantly increase T-1 MRI signal intensity at the tumor site (about two times) and effectively ablate tumor tissues with photoirradiation. Taken together, this work demonstrates the great potential of the MnIO nanoparticles as an ideal theranostic platform for efficient tumor MR imaging and photothermal therapy.
语种: 英语
JCR小类分区: 一区
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内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/3415
Appears in Collections:纳米生物医学与安全研究部_张智军团队_期刊论文

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Recommended Citation:
Zhang, MX,Cao, YH,Wang, LN,et al. Manganese Doped Iron Oxide Theranostic Nanoparticles for Combined T-1 Magnetic Resonance Imaging and Photothermal Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(8):9.
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