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题名: Heterogeneity in cancer stem cells
作者: Wang, AX(王安欣); Chen, LS(陈丽莎); Li, CL(李春林); Zhu, YM(朱毅敏)
通讯作者: Zhu, YM (朱毅敏)
关键词: Cancer stem cell ; Heterogeneity ; Surface marker ; Targeting therapy
刊名: CANCER LETTERS
发表日期: 2015
DOI: 10.1016/j.canlet.2014.11.040
卷: 357, 期:1, 页:6
收录类别: SCI
部门归属: 纳米生物医学与安全研究部
英文摘要: Accumulating evidence suggests that cancer stem cells (CSCs) are heterogeneous populations and their phenotypes are unstable. A number of intrinsic and extrinsic mechanisms contribute to CSC phenotypic variation. The existence of various CSC subpopulations which would lead to a rapid relapse after primary treatments might pose a problem for CSC targeted therapeutics. In order to develop more effective approaches to cancer therapeutics, more CSC-related surface markers or targeting molecules, as well as some novel targeting strategies should be explored. This review summarized the origin and performance of heterogeneity in CSCs and discussed their therapeutic implications. (c) 2014 Elsevier Ireland Ltd. All rights reserved.
语种: 英语
JCR小类分区: 二区
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内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/3441
Appears in Collections:纳米生物医学与安全研究部_朱毅敏团队_期刊论文

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Recommended Citation:
Wang, AX,Chen, LS,Li, CL,et al. Heterogeneity in cancer stem cells[J]. CANCER LETTERS,2015,357(1):6.
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