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题名: Quantification of Zn(II) using a label-free sensor based on graphene oxide and G-quadruplex
作者: Guo, YH(郭亚辉); Sun, Y(孙艳); Shen, XQ(申小强); Chen, X(陈星); Yao, WR; Xie, YF; Hu, JM; Pei, RJ(裴仁军)
通讯作者: Hu, JM
刊名: ANALYTICAL METHODS
发表日期: 2015
DOI: 10.1039/c5ay01840d
卷: 7, 期:22, 页:4
收录类别: SCI
部门归属: 纳米生物医学与安全研究部
英文摘要: By employing two-dimensional and water-soluble graphene oxide (GO), a turn-on sensor was developed for the label-free detection of Zn2+ based on Zn2+-induced G-quadruplex (G4) formation. Indicated using the G4-binding ligand thiazole orange (TO), the enhanced fluorescent signal could be generated only when the guanine-rich DNA was excluded from the surface of GO due to the formation of a G4 induced by Zn2+. The results have shown that the method can be utilized for the detection of Zn2+ in a linear range from 0-30 mu M with a detection limit of 0.71 mu M. The real sample testing conducted in serum samples demonstrated its practical potential in biological analysis.
语种: 英语
JCR小类分区: 三区
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/3450
Appears in Collections:纳米生物医学与安全研究部_裴仁军团队_期刊论文

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Recommended Citation:
Guo, YH,Sun, Y,Shen, XQ,et al. Quantification of Zn(II) using a label-free sensor based on graphene oxide and G-quadruplex[J]. ANALYTICAL METHODS,2015,7(22):4.
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文件名: Quantification of Zn(II) using a label-free sensor based on graphene oxide and G-quadruplex.pdf
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