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题名: Design of a versatile nanocomposite for 'seeing' drug release and action behavior
作者: Zhang, Y; Shen, TT; Deng, X; Ma, YF(马宇飞); Wang, LN; Peng, Y; Wu, J; Zhang, ZJ(张智军); Liu, WS; Tang, Y
通讯作者: Tang, Y
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2015
DOI: 10.1039/c5tb01367d
卷: 3, 期:43, 页:10
收录类别: SCI
部门归属: 纳米生物医学与安全研究部
英文摘要: The capability of monitoring drug release and its action behavior is crucial for understanding the quantitative information regarding drug biodistribution and pharmacokinetic studies. Herein, for the first time, based on the coordination characteristics of rare-earth (RE) ions, including the exchangeable and extendable coordination sphere and their susceptible photoluminescence (PL) intensity to the surrounding coordination environment, we propose a novel concept of drug coordination for the real-time monitoring of drug release using the PL emissions of RE complexes. We chose magnetic-core-coated phenyl mesoporous silica nanoparticles (phMSNs) as the matrix to constrain the Eu(III) complex by strong p-p interactions and hydrophobic property. When the drug was loaded into the channels of the phMSNs shell by the coordination effect, the PL intensity of the Eu(III) complex was enhanced drastically because of the inhibition of energy transfer (ET) from the Eu(III) complex to the shell of phMSNs due to the coordination effect between the drug molecules and Eu(III) ions. Moreover, real-time monitoring could be realized by the recovering of ET with the release of the drug. Most importantly, the Fe3O4 core provides a visualization function for the nanocomposite using the atomic-resolution TEM techniques for finding the precise drug action sites and for elucidating the anticancer action mechanism. As we demonstrated, the nanocomposite killed HeLa cells mainly by attacking their nuclear membranes and nuclei. Therefore, the design of the nanocomposite with an integral composition could be suitable for use with existing clinical applications to determine online the drug concentrations in the tissue regions of interest and drug action behavior in real-time.
语种: 英语
JCR小类分区: 一区
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/3457
Appears in Collections:纳米生物医学与安全研究部_张智军团队_期刊论文

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Recommended Citation:
Zhang, Y,Shen, TT,Deng, X,et al. Design of a versatile nanocomposite for 'seeing' drug release and action behavior[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(43):10.
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