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题名: Gold nanoclusters decorated with magnetic iron oxide nanoparticles for potential multimodal optical/magnetic resonance imaging
作者: Wang, C; Yao, YG(姚亚刚); Song, QJ
通讯作者: Song, QJ
刊名: JOURNAL OF MATERIALS CHEMISTRY C
发表日期: 2015
DOI: 10.1039/c5tc00290g
卷: 3, 期:23, 页:8
收录类别: SCI
部门归属: 先进材料研究部
英文摘要: Efficient nanoprobes for fluorescent and magnetic resonance multimodal imaging (MRI/FI) are in high demand in bioimaging. Herein, a nanoprobe with fluorescent gold nanoclusters (NCs) and magnetic iron oxide composite materials (Fe3O4@AuNCs) was prepared for dual bioimaging. The AuNCs were synthesized using the glutathione (GSH) template. The hydrophobic Fe3O4 magnetic nanoparticles (MNPs) were capped with cetyltrimethyl ammonium bromide (CTAB) to obtain hydrophilic Fe3O4 MNPs. Subsequently, the Fe3O4@AuNCs were prepared by the adsorption of Fe3O4-CTAB on the GSH-AuNCs through electrostatic attraction. The resultant Fe3O4@AuNCs, having an average size of 13.5 nm, can be readily dispersed in water, which displayed a strong red fluorescence (lambda(Em) = 650 nm) with a quantum yield of 4.3%. Confocal laser scanning microscopy studies proved that the Fe3O4@AuNCs have good photostability and low cytotoxicity to 293T cells. The magnetic properties of Fe3O4@AuNCs showed that this material was a T-2-based contrast agent for MRI with a transverse relaxivity r(2) of 20.4 mM(-1) S-1. Furthermore, the signal intensity of the T-2-weighted MRI decreased with an increase in the concentration. The dual optical and magnetic properties of the synthesized Fe3O4@AuNCs were applicable to dual fluorescence and MR-based imaging.
语种: 英语
JCR小类分区: 一区
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内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/3472
Appears in Collections:先进材料研究部_姚亚刚团队_期刊论文

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Recommended Citation:
Wang, C,Yao, YG,Song, QJ. Gold nanoclusters decorated with magnetic iron oxide nanoparticles for potential multimodal optical/magnetic resonance imaging[J]. JOURNAL OF MATERIALS CHEMISTRY C,2015,3(23):8.
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