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题名: Functional Hyperbranched Polylysine as Potential Contrast Agent Probes for Magnetic Resonance Imaging
作者: Zu, GY; Liu, M(刘敏); Zhang, KC(张坤驰); Hong, SN; Dong, JJ; Cao, Y; Jiang, B; Luo, LQ; Pei, RJ(裴仁军)
通讯作者: Pei, RJ(裴仁军)
刊名: BIOMACROMOLECULES
发表日期: 2016
DOI: 10.1021/acs.biomac.6b00605
卷: 17, 期:6
收录类别: SCI
文章类型: 期刊论文
部门归属: 纳米生物医学与安全研究部
英文摘要: Researchers have never stopped questing contrast agents with high resolution and safety to overcome the drawbacks of small-molecule contrast agents in clinic. Herein, we reported the synthesis of gadolinium-based hyperbranched polylysine (HBPLL-DTPA-Gd), which was prepared by thermal polymerization of L-lysine via one-step polycondensation. After conjugating with folic acid, its potential application as MRI contrast agent was then evaluated. This contrast agent had no obvious cytotoxicity as verified by WST assay and H&E analysis. Compared to Gd(III)-diethylenetriamine-pentaacetic acid (Gd-DTPA) (r(1) = 4.3 mM(-1) s(-1)), the FA-HBPLL-DTPA-Gd exhibited much higher longitudinal relaxivity value (r(1) = 13.44 mM(-1) s(-1)), up to 3 times higher than Gd-DTPA. The FA-HBPLL-DTPA-Gd showed significant signal intensity enhancement in the tumor region at various time points and provided a long time window for MR examination. The results illustrate that FA-HBPLL-DTPA-Gd will be a potential candidate for tumor-targeted MRI.
关键词[WOS]: DENDRITIC POLYMERS ; MRI ; DENDRIMERS ; CANCER ; NANOPARTICLES ; BREAST ; TUMORS ; CORES
语种: 英语
JCR小类分区: 二区
WOS记录号: WOS:000377924800043
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4522
Appears in Collections:纳米生物医学与安全研究部_裴仁军团队_期刊论文

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Recommended Citation:
Zu, GY,Liu, M,Zhang, KC,et al. Functional Hyperbranched Polylysine as Potential Contrast Agent Probes for Magnetic Resonance Imaging[J]. BIOMACROMOLECULES,2016,17(6).
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文件名: Functional Hyperbranched Polylysine as Potential Contrast Agent Probes for Magnetic Resonance Imaging.pdf
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