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题名: Tracing mesenchymal stem cells in treated uterine horns trauma of rats with magnetic resonance imaging
作者: Zhou, B; Li, XA; Ding, LJ; Wang, JM; Zang, FC; Cao, Y; Wang, QB(王强斌); Deng, ZW(邓宗武); Dai, JW; Hu, YL
通讯作者: Hu, YL ; Deng, ZW(邓宗武) ; Dai, JW
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
发表日期: 2016
卷: 9, 期:2
收录类别: SCI ; EI
文章类型: 期刊论文
部门归属: 纳米仿生研究部
英文摘要: Stem cells have shown a great promise to treat uterine injury. However, long-term and noninvasive tracking of stem cells in uterine horns is still challenging. In the present study, high-field magnetic resonance imaging (MRI) was applied in the tracking mesenchymal stem cells derived from human umbilical cord blood (UCB-MSCs) in reparation of uterine horns trauma of rats. Nano-sized MR contrast agent SPIO@SiO2 (silica nanoparticle coated super-paramagnetic iron oxide nanoparticle) labeled UCB-MSCs. We found that SPIO@SiO2 labeled UCB-MSCs could be detected in the surgical region in vivo 7 days postoperatively using 7.0 T MRI. By 30 days, the labeled cells only could be detected using 11.7 T MRI in vivo. SPIO@SiO2 labeled UCB-MSCs were mainly in the myometrium and serosal junction area. MRI findings were highly correlated to Prussian blue staining results. Our findings indicate that high-field MRI monitoring of the early phase of this model may provide unique opportunities to study stem cells implantation.
关键词[WOS]: ASHERMANS-SYNDROME ; IN-VITRO ; TRACKING ; MRI ; NANOPARTICLES ; BRAIN
语种: 英语
JCR小类分区: 四区
WOS记录号: WOS:000374655200033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4535
Appears in Collections:纳米仿生研究部_邓宗武团队_期刊论文

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Recommended Citation:
Zhou, B,Li, XA,Ding, LJ,et al. Tracing mesenchymal stem cells in treated uterine horns trauma of rats with magnetic resonance imaging[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2016,9(2).
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文件名: Tracing mesenchymal stem cells in treated uterine horns trauma of rats with magnetic resonance imaging .pdf
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