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题名: A novel photoacoustic nanoprobe of ICG@PEG-Ag2S for atherosclerosis targeting and imaging in vivo
作者: Wu, CX(巫晨昕); Zhang, YJ(张叶俊); Li, Z; Li, CY(李春炎); Wang, QB(王强斌)
通讯作者: Li, CY(李春炎) ; Wang, QB(王强斌)
刊名: NANOSCALE
发表日期: 2016
DOI: 10.1039/c6nr00060f
卷: 8, 期:25
收录类别: SCI ; EI
文章类型: 期刊论文
部门归属: 纳米研究国际实验室
英文摘要: Atherosclerosis is a major cause of cardiovascular and cerebrovascular diseases that have high mortality and disability rates. Because of its unclear pathogenic mechanism and heterogeneous distribution feature, it is still a big challenge to achieve precise diagnosis and therapy of atherosclerosis at its early stage in vivo. Herein, we fabricated a new ICG@PEG-Ag2S nanoprobe by a simple selfassembly of DT-Ag2S QDs, amphipathic C18/PEG polymer molecules and ICG. The ICG@PEG-Ag2S nanoprobe showed relatively long blood retention and was selectively accumulated in the region of atherosclerotic plaque due to the lipophilicity of the C18 chain to the atherosclerosis microenvironment, and thus the atherosclerosis was real-time monitored by high contrastenhanced photoacoustic (PA) imaging of ICG. Combining the high signal-to-noise ratio (SNR) and high spatial resolution fluorescence imaging of Ag2S QDs in the second near-infrared window (NIR-II) and related histological assessment in vitro, the feasibility of this new nanoprobe for atherosclerosis targeting in an Apoe(-/-) mouse model was verified. Additionally, hemolysis and coagulation assays of the ICG@PEG-Ag2S revealed its decent hemocompatibility and no histological changes were observed in the main organs of the mouse. Such a simple, multifunctional nanoprobe for targeting and PA imaging of atherosclerosis will have a great potential for future clinical applications.
关键词[WOS]: NEAR-INFRARED WINDOW ; AG2S QUANTUM DOTS ; INDOCYANINE GREEN ; VISUALIZATION ; NANOPARTICLES ; FLUORESCENCE ; INFLAMMATION ; THERAPY ; TOMOGRAPHY ; TUMORS
语种: 英语
JCR小类分区: 一区
WOS记录号: WOS:000378722100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4639
Appears in Collections:纳米生物医学与安全研究部_王强斌团队_期刊论文

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Recommended Citation:
Wu, CX,Zhang, YJ,Li, Z,et al. A novel photoacoustic nanoprobe of ICG@PEG-Ag2S for atherosclerosis targeting and imaging in vivo[J]. NANOSCALE,2016,8(25).
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