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题名: Facile-synthesized ultrasmall CuS nanocrystals as drug nanocarriers for highly effective chemo-photothermal combination therapy of cancer
作者: Wang, X(王新); Zhang, Q(张倩); Zou, L(周璐); Hu, HS(胡慧珊); Zhang, MX(张萌欣); Dai, JW(戴建武)
通讯作者: Wang, X(王新) ; Dai, JW(戴建武)
刊名: RSC ADVANCES
发表日期: 2016
DOI: 10.1039/c5ra23652e
卷: 6, 期:25
收录类别: SCI ; EI
文章类型: 期刊论文
部门归属: 纳米生物医学与安全研究部
英文摘要: Combinational chemo-photothermal therapy has been considered as a promising strategy to enhance antitumor efficiency via synergistic effects for cancer treatments. Here, we have developed a smart 'all-in-one' platform that conveniently combined chemo-and photothermal therapies based on ultrasmall CuS NCs, which were synthesized using a facile, low cost, and water solution reaction method. Doxorubicin (Dox)-loaded CuS drug nanocarriers (CuS-Dox) were fabricated with loading capacity up to 21%. The resulting CuS-Dox exhibited pH and NIR light dual-responsiveness, demonstrating remarkably promoted Dox release in a weakly acidic environment in cancer cells and enhanced intercellular uptake under 808 nm laser irradiation. Based on in vitro cell cytotoxicity, the CuS-Dox endow excellent chemo-photothermal synergistic effects for cancer cell death or apoptosis, attributed to both the cytotoxicity of light-triggered Dox release and CuS-mediated photothermal ablation. More importantly, in vivo treatment has achieved the complete inhibition of tumor growth in 4T1-bearing mice under a low laser power density of 1.0 W cm(-2). These results demonstrate a better anti-tumor therapeutic efficacy of combined treatment in vitro and in vivo in comparison with chemotherapy or photothermal therapy alone. Our study highlights the promise of fabricating CuS-Dox drug nanocarriers for highly effective chemo-photothermal combination therapy of cancer.
关键词[WOS]: COPPER SULFIDE NANOPARTICLES ; MESOPOROUS SILICA NANOSPHERE ; CORE-SHELL NANOPARTICLES ; GOLD NANORODS ; CONTROLLED-RELEASE ; IN-VIVO ; CONVERSION EFFICIENCY ; DELIVERY SYSTEM ; GRAPHENE OXIDE ; BREAST-CANCER
语种: 英语
JCR小类分区: 二区
WOS记录号: WOS:000371019000060
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4663
Appears in Collections:纳米生物医学与安全研究部_戴建武团队_期刊论文

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Recommended Citation:
Wang, X,Zhang, Q,Zou, L,et al. Facile-synthesized ultrasmall CuS nanocrystals as drug nanocarriers for highly effective chemo-photothermal combination therapy of cancer[J]. RSC ADVANCES,2016,6(25).
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