中国科学院苏州纳米技术与纳米仿生研究所机构知识库
Advanced  
SINANO OpenIR  > 纳米生物医学与安全研究部  > 张智军团队  > 期刊论文
题名: Efficient cancer ablation by combined photothermal and enhanced chemo-therapy based on carbon nanoparticles/doxorubicin@SiO2 nanocomposites
作者: Tu, XL; Wang, LN; Cao, YH; Ma, YF; Shen, H; Zhang, MX(张萌欣); Zhang, ZJ(张智军)
通讯作者: Zhang, ZJ(张智军)
刊名: CARBON
发表日期: 2016
DOI: 10.1016/j.carbon.2015.05.043
卷: 97
收录类别: SCI ; EI
文章类型: 期刊论文
部门归属: 纳米生物医学与安全研究部
英文摘要: The combination of different treatments in cancer therapy has drawn massive attention in the last decades due to its superior anticancer ability to single treatment. One of the most useful strategies to achieve this purpose is to design and construct efficient multifunctional nanoplatforms. Here we report our effort in development of carbon nanoparticles/doxorubicin@SiO2 nanocomposites and their application for combined photothermal and chemotherapy in cancer ablation. The nanocomposites are obtained via reverse microemulsion method with controlled size and high drug loading ratio. These nanocomposites possess high heat-generating ability, pH responsive drug delivery, and heat-induced high drug release as well. In vitro experiment reveals that the combined photothermal and chemotherapy exhibits much higher toxicity to 4T1 cells than photothermal therapy or chemotherapy alone. In vivo experiment reveals that compared with single treatment, the combined photothermal and chemo-therapy can effectively inhibit tumor growth and destroy it eventually without cancer recurrence. The current research demonstrates that carbon nanoparticles/doxorubicin@SiO2 nanocomposites can be used as an efficient nanoplatform for combined cancer photothermal and chemo-therapy. (C) 2015 Elsevier Ltd. All rights reserved.
关键词[WOS]: PEGYLATED GRAPHENE OXIDE ; SILICA-COATED GOLD ; IN-VIVO ; THERANOSTIC PLATFORM ; QUANTUM DOTS ; NANOPARTICLES ; NANOTUBES ; COMBINATION ; TOXICITY ; LIGHT
语种: 英语
JCR小类分区: 一区
WOS记录号: WOS:000366939900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4694
Appears in Collections:纳米生物医学与安全研究部_张智军团队_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Tu-2016-Efficient cancer ablation by combined.pdf(2742KB)期刊论文作者接受稿限制开放View 联系获取全文

Recommended Citation:
Tu, XL,Wang, LN,Cao, YH,et al. Efficient cancer ablation by combined photothermal and enhanced chemo-therapy based on carbon nanoparticles/doxorubicin@SiO2 nanocomposites[J]. CARBON,2016,97.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Tu, XL]'s Articles
[Wang, LN]'s Articles
[Cao, YH]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Tu, XL]‘s Articles
[Wang, LN]‘s Articles
[Cao, YH]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Tu-2016-Efficient cancer ablation by combined.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!