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题名: Chitosan Nanofibers for Specific Capture and Nondestructive Release of CTCs Assisted by pCBMA Brushes
作者: Sun, N(孙娜); Liu, M(刘敏); Wang, JN(王金娥); Wang, ZL(王志利); Li, XP(李新盼); Jiang, B(姜斌); Pei, RJ(裴仁军)
通讯作者: Wang, JN(王金娥) ; Pei, RJ(裴仁军)
刊名: SMALL
发表日期: 2016
DOI: 10.1002/smll.201600475
卷: 12, 期:36
收录类别: SCI ; EI
文章类型: 期刊论文
部门归属: 纳米生物医学与安全研究部
英文摘要: Over the last decade, significant progress has been made to develop sensitive devices for the capture of circulating tumor cells (CTCs) from blood of cancer patients. However, simple capture and counting of CTCs cannot provide effective information for understanding the biology of them. In this work, a functional biointerface is fabricated for specific capture and nondestructive release of CTCs from blood samples. A nanostrucure of porous network based on chitosan nanofibers is fabricated by electrospinning, to mimic the function of extracellular matrices, and then the poly(carboxybetaine methacrylate) (pCBMA) brushes integrating onto nanofiber interface provide the effect of interfacial properties to control nonspecific cell adhesion and the multivalent immobilization of aptamers to induce high efficient and specific CTC capture. Furthermore, a complementary sequence is used to efficiently hybridize with the aptamer to achieve nondestructive release of the captured target cells, assisted by the flexible space provided by pCBMA brushes. This work also shows how nanostructure and the interface molecules regulate the morphology of the captured CTCs, and reveals the importance of the controllable cell morphology on biointerface for an effective nondestructive release of the captured CTCs.
关键词[WOS]: CIRCULATING TUMOR-CELLS ; CANCER-PATIENTS ; EFFICIENT CAPTURE ; APTAMERS ; ANTIBODIES ; INTERFACES ; SUBSTRATE ; SURFACES
语种: 英语
JCR小类分区: 一区
WOS记录号: WOS:000384684500022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4713
Appears in Collections:纳米生物医学与安全研究部_裴仁军团队_期刊论文

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Recommended Citation:
Sun, N,Liu, M,Wang, JN,et al. Chitosan Nanofibers for Specific Capture and Nondestructive Release of CTCs Assisted by pCBMA Brushes[J]. SMALL,2016,12(36).
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