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题名: Enhanced Nanodrug Delivery to Solid Tumors Based on a Tumor Vasculature-Targeted Strategy
作者: Song, CH; Zhang, YJ(张叶俊); Li, CY(李春炎); Chen, GC(陈光村); Kang, XF; Wang, QB(王强斌)
通讯作者: Li, CY(李春炎) ; Wang, QB(王强斌)
刊名: ADVANCED FUNCTIONAL MATERIALS
发表日期: 2016
DOI: 10.1002/adfm.201600417
卷: 26, 期:23
收录类别: SCI ; EI
文章类型: 期刊论文
部门归属: 纳米生物医学与安全研究部
英文摘要: Tumor angiogenesis is a hallmark of tumor growth and metastasis, and inhibition of tumor angiogenesis is an effective strategy for tumor therapy. The high expression levels of specific biomarkers such as integrin receptors (e.g., alpha(v)/beta(3)) in the endothelium of tumor vessels make angiogenesis an ideal target for drug delivery and thus tumor therapy. Herein, a new nanodrug (T&D@RGD-Ag2S) is presented, which can effectively inhibit tumor growth by integrating the specific recognition peptide cyclo(Arg-Gly-Asp-d-Phe-Cys) (cRGD) for tumor vascular targeting, the broad-spectrum endothelial inhibitor O-(chloroacetyl-carbamoyl) fumagillol (TNP-470), and chemotherapeutic drug doxorubicin (DOX) for synergetic tumor therapy. The results show that the T&D@RGD-Ag2S nanodrug rapidly and specifically binds to the tumor vasculature after intravenous injection. Tumor vascular density is greatly reduced following effective angiogenesis inhibition by TNP-470. Meanwhile, increased delivery of DOX deep into the tumor induces extensive tumor apoptosis, resulting in remarkable tumor growth inhibition in a human U87-MG malignant glioma xenograft model. In addition, the therapeutic effects of T&D@RGD-Ag2S on inhibiting tumor growth and decreasing vessel density are monitored in situ using near-infrared II (NIR-II) fluorescence imaging of Ag2S quantum dots. This tumor vasculature-targeted strategy can be extended as a general method for treating a broad range of tumors and holds promise for future clinical applications.
关键词[WOS]: AG2S QUANTUM-DOT ; NEAR-INFRARED WINDOW ; IN-VIVO ; DRUG-DELIVERY ; GOLD NANOPARTICLES ; CANCER-THERAPY ; ANGIOGENESIS ; FLUORESCENCE ; VISUALIZATION ; MICROSPHERES
语种: 英语
JCR小类分区: 一区
WOS记录号: WOS:000379731500016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4720
Appears in Collections:纳米生物医学与安全研究部_王强斌团队_期刊论文

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Recommended Citation:
Song, CH,Zhang, YJ,Li, CY,et al. Enhanced Nanodrug Delivery to Solid Tumors Based on a Tumor Vasculature-Targeted Strategy[J]. ADVANCED FUNCTIONAL MATERIALS,2016,26(23).
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