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题名: Demineralized Bone Matrix Scaffolds Modified by CBD-SDF-1 alpha Promote Bone Regeneration via Recruiting Endogenous Stem Cells
作者: Shi, JJ(施家佳); Sun, J(孙杰); Zhang, W; Liang, H(梁辉); Shi, Q; Li, XR(李晓然); Chen, YY(陈艳艳); Zhuang, Y(庄燕); Dai, JW(戴建武)
通讯作者: Dai, JW(戴建武)
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2016
DOI: 10.1021/acsami.6b08685
卷: 8, 期:41
收录类别: SCI ; EI
文章类型: 期刊论文
部门归属: 纳米生物医学与安全研究部
英文摘要: The reconstruction of bone usually depends on substitute transplantation, which has drawbacks including the limited bone substitutes available, comorbidity, immune rejection, and limited endogenous bone regeneration. Here, we constructed a functionalized bone substitute by combining application of the demineralized bone matrix (DBM) and collagen-binding stromal-cell-derived factor-1 alpha (CBD-SDF-1 alpha). DBM was a poriferous and biodegradable bone substitute, derived from bovine bone and consisting mainly of collagen. CBD-SDF-1 alpha could bind to collagen and be controllably released from the DBM to mobilize stem cells. In a rat femur defect model, CBD-SDF-1 alpha-modified DBM scaffolds could efficiently mobilize CD34(+) and c-kit(+) endogenous stem cells homing to the injured site at 3 days after implantation. According to the data from micro-CT, CBD-SDF-1 alpha-modified DBM scaffolds could help the bone defects rejoin with mineralization accumulated and bone volume expanded. Interestingly, osteoprotegerin (OPG) and osteopontin (OPN) were highly expressed in CBD-SDF-1 alpha group at an early time after implantation, while osteocalcin (OCN) was more expanded. H&E and Massons trichrome staining showed that the CBD-SDF-1 alpha-modified DBM scaffold group had more osteoblasts and that the bone defect rejoined earlier. The ultimate strength of the regenerated bone was investigated by three-point bending, showing that the CBD-SDF-1 alpha group had superior strength. In conclusion, CBD-SDF-1 alpha -modified DBM scaffolds could promote bone regeneration by recruiting endogenous stem cells.
关键词[WOS]: BETA-TRICALCIUM PHOSPHATE ; OSTEOGENIC DIFFERENTIATION ; MORPHOGENETIC PROTEIN-2 ; CALCIUM-PHOSPHATE ; BINDING ; SDF-1-ALPHA ; REPAIR ; ARTHRITIS ; NETWORKS ; STRENGTH
语种: 英语
JCR小类分区: 一区
WOS记录号: WOS:000385992400014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4722
Appears in Collections:纳米生物医学与安全研究部_戴建武团队_期刊论文

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Recommended Citation:
Shi, JJ,Sun, J,Zhang, W,et al. Demineralized Bone Matrix Scaffolds Modified by CBD-SDF-1 alpha Promote Bone Regeneration via Recruiting Endogenous Stem Cells[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(41).
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