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题名: Biodegradable Poly(aminoester)-Mediated p53 Gene Delivery for Cancer Therapy
作者: Shen, H(沈贺); Liu, M(刘敏); Zhang, ZJ(张智军)
通讯作者: Zhang, ZJ(张智军)
刊名: JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
发表日期: 2016
DOI: 10.1166/jnn.2016.10948
卷: 16, 期:3, 页:2210-2217
收录类别: SCI ; EI
文章类型: 期刊论文
部门归属: 纳米生物医学与安全研究部
英文摘要: Gene therapy is a promising strategy in cancer treatment. However, efficient gene translation still remains challenging. In the previous work, a hydrolytically degradable poly(aminoester) with good biocompatibility was synthesized. Herein, the poly(aminoester) was explored as a vector for gene delivery and cancer therapy. The experiments revealed that the poly(aminoester) condensed plasmid DNA into nanosized particles via electrostatic interaction. The pEGFP-N1 and pGL-3 were first used as two reporter genes to study intracellular transfection. The poly(aminoester) showed higher GFP expression (33%) than PEI 25 kDa (21%). Intracellular trafficking of Cy3-labelled pGL-3 also indicated that the poly(aminoester) showed superior DNA delivery ability to nucleus compared to PEI 25 kDa. Furthermore, the therapeutic gene (p53) was translated into the breast cancer cell line (MCF-7), and then induced cell apoptosis. These results suggested that the degradable poly(aminoester) is a promising and efficient gene delivery vector for gene therapeutic applications.
关键词[WOS]: ENTRAPPED GOLD NANOPARTICLES ; IN-VITRO ; TRANSFECTION ; POLYETHYLENIMINE ; VECTORS ; PROLIFERATION ; APOPTOSIS ; POLYMERS ; PROTEIN ; CELLS
语种: 英语
JCR小类分区: 三区
WOS记录号: WOS:000374153800012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4725
Appears in Collections:纳米生物医学与安全研究部_张智军团队_期刊论文

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Recommended Citation:
Shen, H,Liu, M,Zhang, ZJ. Biodegradable Poly(aminoester)-Mediated p53 Gene Delivery for Cancer Therapy[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(3):2210-2217.
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文件名: Biodegradable Poly(aminoester)-Mediated p53 Gene Delivery for Cancer Therapy.pdf
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