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题名: Magnetic Resonance Imaging Revealed Splenic Targeting of Canine Parvovirus Capsid Protein VP2
作者: Ma, YF; Wang, HM; Yan, D; Wei, YQ; Cao, YH(曹玉华); Yi, PW(易佩伟); Zhang, HL(张海禄); Deng, ZW(邓宗武); Dai, JW(戴建武); Liu, XT; Luo, JX; Zhang, ZJ(张智军); Sun, SQ; Guo, HC
通讯作者: Sun, SQ ; Guo, HC ; Zhang, ZJ(张智军)
刊名: SCIENTIFIC REPORTS
发表日期: 2016
DOI: 10.1038/srep23392
卷: 6
收录类别: SCI
文章类型: 期刊论文
部门归属: 纳米生物医学与安全研究部
英文摘要: Canine parvovirus (CPV) is a highly contagious infectious virus, whose infectious mechanism remains unclear because of acute gastroenteritis and the lack of an efficient tool to visualize the virus in real time during virology research. In this study, we developed an iron oxide nanoparticle supported by graphene quantum dots (GQD), namely, FeGQD. In this composite material, GQD acts as a stabilizer; thus, vacancies are retained on the surface for further physical adsorption of the CPV VP2 protein. The FeGQD@VP2 nanocomposite product showed largely enhanced colloidal stability in comparison with bare FeGQD, as well as negligible toxicity both in vitro and in vivo. The composite displayed high uptake into transferrin receptor (TfR) positive cells, which are distinguishable from FeGQD or TfR negative cells. In addition, the composite developed a significant accumulation in spleen rather than in liver, where bare FeGQD or most iron oxide nanoparticles gather. As these evident targeting abilities of FeGQD@VP2 strongly suggested, the biological activity of CPV VP2 was retained in our study, and its biological functions might correspond to CPV when the rare splenic targeting ability is considered. This approach can be applied to numerous other biomedical studies that require a simple yet efficient approach to track proteins in vivo while retaining biological function and may facilitate virus-related research.
关键词[WOS]: VIRUS-LIKE PARTICLES ; NANOPARTICLES ; BIODISTRIBUTION ; TOXICITY ; CLEARANCE ; VARIANTS ; MICE ; DOGS
语种: 英语
JCR小类分区: 二区
WOS记录号: WOS:000372512500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4750
Appears in Collections:纳米生物医学与安全研究部_张智军团队_期刊论文

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Recommended Citation:
Ma, YF,Wang, HM,Yan, D,et al. Magnetic Resonance Imaging Revealed Splenic Targeting of Canine Parvovirus Capsid Protein VP2[J]. SCIENTIFIC REPORTS,2016,6.
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文件名: Magnetic Resonance Imaging Revealed Splenic Targeting of Canine Parvovirus Capsid Protein VP2 (1).pdf
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