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题名: The Use of Metal Coordination in Peptide and Protein Research
作者: Ma, XC(马晓川); Fei, H(费浩)
通讯作者: Fei, H(费浩)
刊名: PROGRESS IN CHEMISTRY
发表日期: 2016
DOI: 10.7536/PC150625
卷: 28, 期:2017-02-03
收录类别: SCI
文章类型: 期刊论文
部门归属: 纳米生物医学与安全研究部
英文摘要: Metal ions are commonly seen in naturally occurring protein molecules, and often play pivotal roles in protein function. Deepening understanding of basic coordination models between amino acids and various metals facilitates artificial designs of novel peptide-metal coordination modalities that can be broadly applied in research fields such as peptide structure-function optimization, molecular assembly, labeling and imaging, and peptide therapeutics development. This minireview introduces the basic coordination chemistry between electron-donating groups on peptides ( namely carboxylate, amine, imidazole, sulfhydryl groups) and their respective favorable metal ions with illustrated examples. We next discuss in detail the use of metal or metalloid coordination in fundamental research of peptides and proteins, including secondary structure constraining, supermolecular assembly, fluorescence or phosphorescence labeling, and protein folding analysis. In particular, we highlight two examples of luminogenic peptide/protein labeling techniques, the first being the broadly applied biarsenical ligand and tetracysteine motif based protein probing method, and the second being the recently reported iridium (III) complex and histidine motif based peptide labeling technique. Finally we discuss the principles in the development of metallo-peptide molecular probes and the potential brought by this research for optimization in drug designs.
关键词[WOS]: ALZHEIMERS-DISEASE ; ION COORDINATION ; AS(III) BINDING ; BETA-PEPTIDE ; TROPONIN-C ; DESIGN ; ZINC ; CONFORMATION ; COMPLEX ; FLASH
语种: 英语
JCR小类分区: 四区
WOS记录号: WOS:000374083300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4751
Appears in Collections:纳米生物医学与安全研究部_费浩团队_期刊论文

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Recommended Citation:
Ma, XC,Fei, H. The Use of Metal Coordination in Peptide and Protein Research[J]. PROGRESS IN CHEMISTRY,2016,28(2017-02-03).
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文件名: 金属配位在多肽与蛋白质研究中的应用.pdf
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