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题名: Radially Aligned Electrospun Fibers with Continuous Gradient of SDF1 alpha for the Guidance of Neural Stem Cells
作者: Li, XR(李晓然); Li, MY(李梦媛); Sun, J; Zhuang, Y(庄燕); Shi, JJ(施家佳); Guan, DW(关东伟); Chen, YY(陈艳艳); Dai, JW(戴建武)
通讯作者: Dai, JW(戴建武)
刊名: SMALL
发表日期: 2016
DOI: 10.1002/smll.201601285
卷: 12, 期:36
收录类别: SCI ; EI
文章类型: 期刊论文
部门归属: 纳米生物医学与安全研究部
英文摘要: Repair of spinal cord injury will require enhanced recruitment of endogenous neural stem cells (NSCs) from the central canal region to the lesion site to reestablish neural connectivity. The strategy toward this goal is to provide directional cues, e.g., alignment topography and biological gradients from the rostral and caudal ends toward the center. This study demonstrates a facile method for fabrication of continuous gradients of stromal-cell-derived factor-1 alpha (SDF1 alpha) embedded in the radially aligned electrospun collagen/poly (e-caprolactone) mats. Gradients can be readily produced in a controllable and reproducible fashion by adjusting the collection time and collector size during electrospinning. To get a long-term gradient, the SDF1 alpha is fused with a unique peptide of collagen-binding domain (CBD), which can bind to collagen specifi cally. Aligned CBD-SDF1 alpha gradients show stable, sustained, and gradual release during 7 d. Further, the effect of aligned CBD-SDF1 alpha gradients on the guidance of NSCs is investigated. It is found that the CBD-SDF1 alpha gradient scaffolds direct and enhance NSC migration from the periphery to the center along the aligned electrospun fi bers. Taken together, the tubular conduits based on radially aligned electrospun fi bers with continuous SDF1 alpha gradient show great potential for guiding nerve regeneration.
关键词[WOS]: SPINAL-CORD-INJURY ; PROMOTES FUNCTIONAL RECOVERY ; FACIAL-NERVE REGENERATION ; COLLAGEN SCAFFOLDS ; STEM/PROGENITOR CELLS ; NANOFIBER SCAFFOLDS ; NEURITE OUTGROWTH ; ANTIBODY FRAGMENT ; MIGRATION ; TRANSPLANTATION
语种: 英语
JCR小类分区: 一区
WOS记录号: WOS:000384684500012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4795
Appears in Collections:纳米生物医学与安全研究部_戴建武团队_期刊论文

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Recommended Citation:
Li, XR,Li, MY,Sun, J,et al. Radially Aligned Electrospun Fibers with Continuous Gradient of SDF1 alpha for the Guidance of Neural Stem Cells[J]. SMALL,2016,12(36).
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