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题名: Oligoethylenimine grafted PEGylated poly(aspartic acid) as a macromolecular contrast agent: properties and in vivo studies
作者: Jiang, B(姜斌); Liu, M(刘敏); Zhang, KC(张坤驰); Zu, GY(祖广月); Dong, JJ(董京金); Cao, Y(曹翼); Zhang, L; Pei, RJ(裴仁军)
通讯作者: Pei, RJ(裴仁军)
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2016
DOI: 10.1039/c6tb00278a
卷: 4, 期:19
收录类别: SCI ; EI
文章类型: 期刊论文
部门归属: 纳米生物医学与安全研究部
英文摘要: PEGylated poly(aspartate-g-OEI) was developed as a magnetic resonance imaging probe. The PEG-PBLA block copolymer was prepared by the ring-opening polymerization of beta-benzyl-L-aspartate N-carboxy-anhydride (BLA-NCA) initiated by the terminal primary amino group of mPEG-NH2, followed by grafting with oligoethylenimine (OEI, M-w = 800) and Gd-DTPA. Compared to Gd-DTPA (4.42 mM(-1) s(-1)), PEG-p(Asp-OEI-DTPA-Gd) exhibited much higher T-1 relaxivity (19.03 mM(-1) s(-1)), up to 4.3 times higher than Gd-DTPA. No obvious cytotoxicity was observed from the WST assay and H&E analysis, which illustrated that this macromolecular contrast agent (mCA) exhibited excellent biocompatibility. Folic acid (FA) was further labeled onto the mCA to endow the mCA with targeting ability. During in vivo animal studies, the FA labeled MRI probes showed a significant signal intensity enhancement in the tumor during different time intervals and provided a long and efficient window time for MR examination. These results suggest that such mCAs are excellent candidates as magnetic resonance imaging (MRI) probes with high efficiency and safety.
关键词[WOS]: EFFICIENT GENE DELIVERY ; PEPTIDE DENDRIMERS ; BLOCK-COPOLYMERS ; DRUG-DELIVERY ; NANOPARTICLES ; RELAXIVITY ; PEG ; COMPLEXES ; LIPOSOMES ; VECTORS
语种: 英语
JCR小类分区: 一区
WOS记录号: WOS:000376039100017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4839
Appears in Collections:纳米生物医学与安全研究部_裴仁军团队_期刊论文

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Recommended Citation:
Jiang, B,Liu, M,Zhang, KC,et al. Oligoethylenimine grafted PEGylated poly(aspartic acid) as a macromolecular contrast agent: properties and in vivo studies[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(19).
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