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题名: 915 nm Light-Triggered Photodynamic Therapy and MR/CT Dual-Modal Imaging of Tumor Based on the Nonstoichiometric Na0.52YbF3.52:Er Upconversion Nanoprobes
作者: Huang, YA(皇亚楠); Xiao, QB(肖清波); Hu, HS(胡慧珊); Zhang, KC(张坤驰); Feng, YM(封雅敏); Li, FJ(李付锦); Wang, J(王健); Ding, XG(丁显光); Jiang, J(姜江); Li, YF; Shi, LY; Lin, HZ(蔺洪振)
通讯作者: Xiao, QB(肖清波) ; Lin, HZ(蔺洪振)
刊名: SMALL
发表日期: 2016
DOI: 10.1002/smll.201601023
卷: 12, 期:31
收录类别: SCI ; EI
文章类型: 期刊论文
部门归属: 纳米研究国际实验室
英文摘要: Lanthanide (Ln(3+))-doped upconversion nanoparticles (UCNPs) as a new generation of multimodal bioprobes have attracted great interest for theranostic purpose. Herein, red emitting nonstoichiometric Na0.52YbF3.52:Er UCNPs of high luminescence intensity and color purity are synthesized via a facile solvothermal method. The red UC emission from the present nanophosphors is three times more intense than the well-known green emission from the approximate to 30 nm sized hexagonal-phase NaYF4:Yb,Er UCNPs. By utilizing Na0.52YbF3.52:Er@SrF2 UCNPs as multifunctional nanoplatforms, highly efficient in vitro and in vivo 915 nm light-triggered photodynamic therapies are realized for the first time, with dramatically diminished overheating yet similar therapeutic effects in comparison to those triggered by 980 nm light. Moreover, by virtue of the high transverse relaxivity (r(2)) and the strong X-ray attenuation ability of Yb3+ ions, these UCNPs also demonstrate good performances as contrast agents for high contrast magnetic resonance and X-ray computed tomography dual-modal imaging. Our research shows the great potential of the red emitting Na0.52YbF3.52:Er UCNPs for multimodal imaging-guided photodynamic therapy of tumors.
关键词[WOS]: NEAR-INFRARED LIGHT ; DRUG-DELIVERY ; NANO-BIOPROBES ; UPCONVERTING NANOPARTICLES ; CANCER-THERAPY ; RED-EMISSION ; NANOCRYSTALS ; LUMINESCENCE ; PHOTOSENSITIZERS ; NAYF4YB3+,ER3+
语种: 英语
JCR小类分区: 一区
WOS记录号: WOS:000383376300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4846
Appears in Collections:纳米研究国际实验室_蔺洪振团队_期刊论文

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Recommended Citation:
Huang, YA,Xiao, QB,Hu, HS,et al. 915 nm Light-Triggered Photodynamic Therapy and MR/CT Dual-Modal Imaging of Tumor Based on the Nonstoichiometric Na0.52YbF3.52:Er Upconversion Nanoprobes[J]. SMALL,2016,12(31).
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