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题名: The development of a light-up red-emitting fluorescent probe based on a G-quadruplex specific cyanine dye
作者: Chen, X(陈星); Wang, J(王金娥); Jiang, GM(江桂梅); Zu, GY(祖广月); Liu, M(刘敏); Zhou, L(周璐); Pei, RJ(裴仁军)
通讯作者: Pei, RJ(裴仁军)
刊名: RSC ADVANCES
发表日期: 2016
DOI: 10.1039/c6ra11152a
卷: 6, 期:74
收录类别: SCI ; EI
文章类型: 期刊论文
部门归属: 纳米生物医学与安全研究部
英文摘要: A cyanine dye-dimethylindole red containing an extending polymethine chain, a sterically bulky dimethylindole heterocycle and an anionic propylsulfonate substituent on the quinoline ring was found to behave as a high specific light-up G-quadruplex probe in the red-emitting region above 650 nm, especially for parallel G-quadruplex c-myc. The 10 to 70-fold enhancement in the fluorescence quantum yield of dimethylindole red when incubating with G-quadruplexes may benefit more accurate definition of the distribution of G-quadruplexes across the genome.
关键词[WOS]: PARALLEL G-QUADRUPLEXES ; NAPHTHALENE DIIMIDE DYAD ; SWITCH-ON PROBE ; DISPLACEMENT ASSAY ; NUCLEIC-ACIDS ; DNA ; PROMOTER ; TRANSCRIPTION ; SELECTIVITY ; AFFINITY
语种: 英语
JCR小类分区: 二区
WOS记录号: WOS:000381512800057
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4911
Appears in Collections:纳米生物医学与安全研究部_裴仁军团队_期刊论文

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Recommended Citation:
Chen, X,Wang, J,Jiang, GM,et al. The development of a light-up red-emitting fluorescent probe based on a G-quadruplex specific cyanine dye[J]. RSC ADVANCES,2016,6(74).
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