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题名: Gadolinium functionalized carbon dots for fluorescence/magnetic resonance dual-modality imaging of mesenchymal stem cells
作者: Chen, Hao; Wang, Lina; Fu, Han; Wang, Zhiying; Xie, Yujie; Zhang, Zhijun(张智军); Tang, Yu
通讯作者: Tang, Y ; Zhang, Zhijun(张智军)
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2016
DOI: 10.1039/c6tb01422d
卷: 4, 期:46
收录类别: SCI ; EI
文章类型: 期刊论文
部门归属: 纳米生物医学与安全研究部
英文摘要: The development of multimodal nanoprobes is of great importance in nanomedicine because it integrates the advantages of each imaging modality and offers a significantly enhanced diagnostic effect. In this work, gadolinium(III) functionalized fluorescent carbon dots (Gd-CDs) are synthesized by means of a one-step hydrothermal approach. As a fluorescent nanomaterial, the obtained Gd-CDs exhibit strong and stable fluorescence with excitation-independent emission behavior. Moreover, as an MRI contrast agent, the Gd-CDs exhibited a longitudinal relaxation rate of 6.06 mM(-1) s(-1), which is significantly higher than that of the commercially available MRI agent Gadovist (4.24 mM(-1) s(-1)). In addition, the cellular experiment reveals that Gd-CDs promote the proliferation of human mesenchymal stem cells (hMSCs), which is tracked by the fluorescence/Magnetic Resonance dual-modality imaging of hMSCs by the Gd-CDs.
关键词[WOS]: GRAPHENE QUANTUM DOTS ; NEPHROGENIC SYSTEMIC FIBROSIS ; MRI CONTRAST AGENTS ; IN-VIVO ; SURFACE-STATE ; ENDOTHELIAL-CELLS ; CANCER-THERAPY ; DRUG-DELIVERY ; NANODOTS ; FLUORESCENT
语种: 英语
JCR小类分区: 一区
WOS记录号: WOS:000389666000015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4922
Appears in Collections:纳米生物医学与安全研究部_张智军团队_期刊论文

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Recommended Citation:
Chen, Hao,Wang, Lina,Fu, Han,et al. Gadolinium functionalized carbon dots for fluorescence/magnetic resonance dual-modality imaging of mesenchymal stem cells[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(46).
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文件名: Chen-2016-Gadolinium functionalized carbon dot.pdf
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