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题名: Preparation of linear poly(glycerol) as a T-1 contrast agent for tumor-targeted magnetic resonance imaging
作者: Cao, Y(曹翼); Liu, M(刘敏); Zhang, KC(张坤驰); Dong, JJ(董京金); Zu, GY(祖广月); Chen, Y(陈阳); Zhang, TT; Xiong, DS; Pei, RJ(裴仁军)
通讯作者: Pei, RJ(裴仁军)
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2016
DOI: 10.1039/c6tb01514j
卷: 4, 期:41
收录类别: SCI ; EI
文章类型: 期刊论文
部门归属: 纳米生物医学与安全研究部
英文摘要: Macromolecular contrast agents (CAs) labeled with targeting molecules are gaining remarkable interest as promising materials overcoming the defects of small-molecule CAs. Designed on the basis of biocompatible poly(glycerol) (PG), a linear macromolecular contrast agent (CA) was synthesized with a composition of PG as a backbone and partial hydroxyl connected with gadolinium labeled poly(L-lysine) dendrons, where folic acid was also conjugated. This linear CA exhibited higher relaxivity (7.04 mM(-1) S-1) relative to Magnevists (3.98 mM(-1) S-1), and showed negligible toxicity determined by WST assay and histological analysis. In vitro and in vivo magnetic resonance imaging (MRI) measurements presented obvious target specificity to KB cells and tumor. Moreover, high signal enhancement was observed in the tumor region at various time points after intravenous injection to ensure the long time window for imaging. All the findings make it an attractive candidate for tumor-targeted MRI CAs.
关键词[WOS]: CLICK CHEMISTRY ; GADOLINIUM CHELATE ; MRI ; DENDRIMERS ; RELAXIVITY ; DELIVERY ; PHARMACOKINETICS ; MACROMOLECULES ; CYCLODEXTRIN ; POLYGLYCEROL
语种: 英语
JCR小类分区: 一区
WOS记录号: WOS:000386336300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sinano.ac.cn/handle/332007/4924
Appears in Collections:纳米生物医学与安全研究部_裴仁军团队_期刊论文

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Recommended Citation:
Cao, Y,Liu, M,Zhang, KC,et al. Preparation of linear poly(glycerol) as a T-1 contrast agent for tumor-targeted magnetic resonance imaging[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(41).
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